He currently plays for SP Domagnano, wearing the number 19 shirt. He plays primarily as a Midfield.

His most recent move was a from SP Domagnano to ASD Comacchiese 2015 on 2025-07-01.

Across 21 appearances in the San Marino Campionato di Calcio 2024-2025, Manuel Mazzavillani registered 0 goals and 0 assists, while completing 0 key passes out of 0 total passes with a passing accuracy of -.